ULTRASOUND NEUROMODULATION
working on the next generation of non-invasive brain stimulation
Ultrasound can make visible what is hidden, for example, to give parents a glimpse of their child before birth. We are now putting these high-frequency sound waves – beyond the range of human hearing – to use for a wholly different purpose: to manipulate the activity of the brain.
Beams of ultrasound can be safely focused at a millimetre scale, even deep within the brain, and modulate neural activity. Ultrasound has the potential to provide new insights into how the brain works and help us develop new treatments for neurological and psychiatric disorders.
Breaking new ground in such a way requires an integrative, cross-species approach. It requires a systems level combination of neuromodulation and neuroimaging techniques.
Ultrasound can be safely focused at a millimetre scale, even deep within the brain, and modulate neural activity. Ultrasound thus has the potential to provide new insights into how the brain works and help us develop new treatments for neurological and psychiatric disorders.
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"The brain is not porridge" <Dick Passingham> The brain is highly differentiated and structured. Not one bit is like any other. At the same time, no bit acts alone: each region is highly...
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Our human cognitive skills trump those of our primate relatives in many domains, ranging from logical reasoning to managing complex social lives and from tool-use to language. A basic yet powerful faculty might underlie many of these characteristic functions of the human mind: instant conceptual inference.
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The evolutionary emergence of our human ability to quickly infer upon conceptual relationships likely relies on the relative re-organization of large-scale connections in the human brain compared to those in other primates since our last common ancestor.
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neuromodulation
transcranial ultrasound (TUS), magnetic (TMS), and electric (TCS) brain stimulation
neuroimaging
functional magnetic resonance imaging (fMRI)
connectivity
functional MRI connectivity and diffusion-weighted MRI tractography
electrophysiology
magneto- (MEG) and electro- (EEG) encephalography
computational modelling
behavioural, cognitive, and neural models of action, communication, and learning
behaviour
motion analysis of grasping and pointing
MrCat
Magnetic Resonance Comparative Anatomy ToolboxHCP pipelines
Human Connectome Project - Structural Analysis Pipelinekinemagic
Motion Analysis ToolboxEEG-TMS
FieldTrip extension for concurrent EEG-TMS analysisReferential pointing is a characteristically human behavior, which involves moving a nger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and...
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Referential pointing is a characteristically human behavior, which involves moving a nger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and...
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Referential pointing is a characteristically human behavior, which involves moving a nger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and...
continue >
Referential pointing is a characteristically human behavior, which involves moving a nger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and...
continue >
Referential pointing is a characteristically human behavior, which involves moving a nger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and...
continue >
Referential pointing is a characteristically human behavior, which involves moving a nger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and...
continue >
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Donders Centre for Cognition
Montessorilaan 3, room B.01.04
6525 HR Nijmegen
the Netherlands
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