Verhagen, Gallea – eLife – Offline impact of transcranial focused ultrasound on cortical activation in primates

Referential pointing is a characteristically human behavior, which involves moving a nger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and conceptual abilities. A simple interface could supplement spatially-guided motor routines with communicative-ostensive cues. For instance, a pointing nger held still for […]

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ultrasound neuromodulation

Ultrasound can be safely focused at a millimetre scale, even deep within the brain, and modulate neural activity. Ultrasound thus has the potential to provide new insights into how the brain works and help us develop new treatments for neurological and psychiatric disorders.

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Folloni, Verhagen – Neuron – Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation

Referential pointing is a characteristically human behavior, which involves moving a nger through space to direct an addressee towards a desired mental state. Planning this type of action requires an interface between sensorimotor and conceptual abilities. A simple interface could supplement spatially-guided motor routines with communicative-ostensive cues. For instance, a pointing nger held still for […]

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Zimmermann – eNeuro – The extrastriate body area computes desired goal states during action planning

How do object perception and action interact at a neural level? Here we test the hypothesis that perceptual features, processed by the ventral visuoperceptual stream, are used as priors by the dorsal visuomotor stream to specify goal-directed grasping actions. We present three main findings, which were obtained by combining time-resolved transcranial magnetic stimulation and kinematic […]

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Johnen – eLife – Causal manipulation of functional connectivity in a specific neural pathway during behaviour and at rest

Correlations in brain activity between two areas (functional connectivity) have been shown to relate to their underlying structural connections. We examine the possibility that functional connectivity also reflects short-term changes in synaptic efficacy. We demonstrate that paired transcranial magnetic stimulation (TMS) near ventral premotor cortex (PMv) and primary motor cortex (M1) with a short 8-ms […]

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Stolk – Cortex – Understanding communicative actions: A repetitive TMS study

Despite the ambiguity inherent in human communication, people are remarkably efficient in establishing mutual understanding. Studying how people communicate in novel settings provides a window into the mechanisms supporting the human competence to rapidly generate and understand novel shared symbols, a fundamental property of human communication. Previous work indicates that the right posterior superior temporal […]

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Verhagen – JNeurosci – Hierarchical organization of parietofrontal circuits during goal-directed action

Two parietofrontal networks share the control of goal-directed movements: a dorsomedial circuit that includes the superior parieto- occipital sulcus (sPOS) and a dorsolateral circuit comprising the anterior intraparietal sulcus (aIPS). These circuits are thought to independently control either reach and grip components (a functional dissociation), or planning and execution phases of grasping movements (a temporal […]

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Toolkit for Transcranial Brain Stimulation (2-4 sept)

Nijmegen, September 2-4, 2013 This intensive three-day toolkit course will provide in-depth knowledge on transcranial magnetic stimulation (TMS) and transcranial current stimulation (tDCS/tACS). The course will cover both basic and advanced topics, including multi-modal applications of non-invasive brain stimulation (with a focus on TMS/tDCS and EEG). The course involves a series of lectures, discussions, and […]

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Verhagen – JNeurosci – Cortical dynamics of sensorimotor integration during grasp planning

Our sensorimotor interactions with objects are guided by their current spatial and perceptual features, as well as by learned object knowledge. A fresh red tomato is grasped differently than a soft overripe tomato, even when those objects possess the same spatial metrics of size and shape. Objects’ spatial and perceptual features need to be integrated […]

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Verhagen – thesis – How to grasp a ripe tomato

Fortunately, we don’t have to think about this when we are standing in the supermarket after a busy day. We carefully grasp that ripe tomato without effort. Such a fluent integration of abstract knowledge (“that tomato is ripe”) and spatial information (“it is there”) is actually extraordinary. While modern computers beat grandmasters in chess, not […]

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Volman – CurrBio – Anterior prefrontal cortex inhibition impairs control over social emotional actions

When dealing with emotional situations, we often need to rapidly override automatic stimulus-response mappings and select an alternative course of action [1], for instance, when trying to manage, rather than avoid, another’s aggres- sive behavior. The anterior prefrontal cortex (aPFC) has been linked to the control of these social emotional behav- iors [2, 3]. We […]

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Kammers – JCogNeuro – Is this hand for real? Attenuation of the rubber hand illusion by transcranial magnetic stimulation over the inferior parietal lobule

In the well-known rubber hand illusion (RHI), watching a rubber hand being stroked while one’s own unseen hand is synchronously stroked, induces a relocation of the sensed position of one’s own hand towards the rubber hand. As one has lost the veridical location of one’s hand, one should not be able to correctly guide one’s […]

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