Zimmermann – eNeuro – The extrastriate body area computes desired goal states during action planning

How do object perception and action interact at a neural level? Here we test the hypothesis that perceptual features, processed by the ventral visuoperceptual stream, are used as priors by the dorsal visuomotor stream to specify goal-directed grasping actions. We present three main findings, which were obtained by combining time-resolved transcranial magnetic stimulation and kinematic […]

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Johnen – eLife – Causal manipulation of functional connectivity in a specific neural pathway during behaviour and at rest

Correlations in brain activity between two areas (functional connectivity) have been shown to relate to their underlying structural connections. We examine the possibility that functional connectivity also reflects short-term changes in synaptic efficacy. We demonstrate that paired transcranial magnetic stimulation (TMS) near ventral premotor cortex (PMv) and primary motor cortex (M1) with a short 8-ms […]

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Volman – JNeurosci – Reduced serotonin transporter availability decreases prefrontal control of the amygdala

After a threatening event, the risk of developing social psychopathologies is increased in short-allele (s) carriers of the serotonin trans- porter gene. The amygdala becomes overresponsive to emotional stimuli, an effect that could be driven by local hypersensitivity or by reduced prefrontal regulation. This study distinguishes between these two hypotheses by using dynamic causal modeling […]

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Verhagen – JNeurosci – Hierarchical organization of parietofrontal circuits during goal-directed action

Two parietofrontal networks share the control of goal-directed movements: a dorsomedial circuit that includes the superior parieto- occipital sulcus (sPOS) and a dorsolateral circuit comprising the anterior intraparietal sulcus (aIPS). These circuits are thought to independently control either reach and grip components (a functional dissociation), or planning and execution phases of grasping movements (a temporal […]

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Verhagen – JNeurosci – Cortical dynamics of sensorimotor integration during grasp planning

Our sensorimotor interactions with objects are guided by their current spatial and perceptual features, as well as by learned object knowledge. A fresh red tomato is grasped differently than a soft overripe tomato, even when those objects possess the same spatial metrics of size and shape. Objects’ spatial and perceptual features need to be integrated […]

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Verhagen – thesis – How to grasp a ripe tomato

How to grasp a ripe tomato? Fortunately, we don’t have to think about this when we are standing in the supermarket after a busy day. We carefully grasp that ripe tomato without effort. Such a fluent integration of abstract knowledge (“that tomato is ripe”) and spatial information (“it is there”) is actually extraordinary. While modern […]

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conceptual-motor interactions

In my scientific career I have been continuously fascinated by the interaction between conceptual and motoric faculties of our brain and how they together support uniquely human behaviour.

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Volman – CurrBio – Anterior prefrontal cortex inhibition impairs control over social emotional actions

When dealing with emotional situations, we often need to rapidly override automatic stimulus-response mappings and select an alternative course of action [1], for instance, when trying to manage, rather than avoid, another’s aggres- sive behavior. The anterior prefrontal cortex (aPFC) has been linked to the control of these social emotional behav- iors [2, 3]. We […]

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Kammers – JCogNeuro – Is this hand for real? Attenuation of the rubber hand illusion by transcranial magnetic stimulation over the inferior parietal lobule

In the well-known rubber hand illusion (RHI), watching a rubber hand being stroked while one’s own unseen hand is synchronously stroked, induces a relocation of the sensed position of one’s own hand towards the rubber hand. As one has lost the veridical location of one’s hand, one should not be able to correctly guide one’s […]

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Kammers – Neuropsy – The rubber hand illusion in action

In the rubber hand illusion (RHI), participants incorporate a rubber hand into a mental representation of one’s body. This deceptive feeling of ownership is accompanied by recalibration of the perceived position of the participant’s real hand toward the rubber hand. Neuroimaging data suggest involvement of the posterior parietal lobule during induction of the RHI, when […]

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Verhagen – JNeurosci – Perceptuo-motor interaction during prehension movements

Adaptive behavior relies on the integration of perceptual and motor processes. In this study, we aimed at characterizing the cerebral processes underlying perceptuo-motor interactions evoked during prehension movements in healthy humans, as measured by means of functional magnetic resonance imaging. We manipulated the viewing conditions (binocular or monocular) during planning of a prehen- sion movement, […]

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Grol – JNeurosci – Parieto-frontal connectivity during visually guided grasping

Grasping an object requires processing visuospatial information about the extrinsic features (spatial location) and intrinsic features (size, shape, orientation) of the object. Accordingly, manual prehension has been subdivided into a reach component, guiding the hand toward the object on the basis of its extrinsic features, and a grasp component, preshaping the fingers around the center […]

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Majdandzic – NeuroImg – The role of immediate and final goals in action planning: an fMRI study

To interact effectively with our environment, we need to specify the intended outcomes (goals) of our actions. In this process, immediate goals and final goals can be regarded as different levels within a hierarchically organized system for action planning: immediate goals and movement details are selected to accomplish more remote goals. Behavioral studies support this […]

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