Led by Rogier Mars we describe in a new paper in Neuroscience and Biobehavioral Reviews how the brain’s organisation can be investigated across humans and other primates. Using the same non-invasive technique across species we can directly compare brains, regions, and/or connections in an quantitative and intuitive manner. The trick is to map how regions are connected with each other. The resulting connectivity profiles are a good indication of a region’s role in the bigger picture. Interestingly, these connectivity profiles are remarkably preserved across related species (maybe evolution is not “just a theory” after all). We set out how these profiles can be used to reveal both similarities across species – to identify connectivity homologues – and to reveal differences – to identify species-unique regions and connections.